Is Particle Pollution in Outdoor Air Associated with Metabolic Control in Type 2 Diabetes?

نویسندگان

  • Teresa Tamayo
  • Wolfgang Rathmann
  • Ursula Krämer
  • Dorothea Sugiri
  • Matthias Grabert
  • Reinhard W. Holl
چکیده

BACKGROUND There is growing evidence that air pollutants are associated with the risk of type 2 diabetes. Subclinical inflammation may be a mechanism linking air pollution with diabetes. Information is lacking whether air pollution also contributes to worse metabolic control in newly diagnosed type 2 diabetes. We examined the hypothesis that residential particulate matter (PM10) is associated with HbA1c concentration in newly diagnosed type 2 diabetes. METHODS Nationwide regional levels of particulate matter with a diameter of ≤ 10 µm (PM10) were obtained in 2009 from background monitoring stations in Germany (Federal Environmental Agency) and assigned to place of residency of 9,102 newly diagnosed diabetes patients registered in the DPV database throughout Germany (age 65.5 ± 13.5 yrs; males: 52.1%). Mean HbA1c (%) levels stratified for air pollution quartiles (PM10 in µg/m(3)) were estimated using linear regression models adjusting for age, sex, BMI, diabetes duration, geographic region, year of ascertainment, and social indicators. FINDINGS In both men and women, adjusted HbA1c was significantly lower in the lowest quartile of PM10 exposure in comparison to quartiles Q2-Q4. Largest differences in adjusted HbA1c (95% CI) were seen comparing lowest quartiles of exposure with highest quartiles (men %: -0.42 (-0.62; -0.23)/mmol/mol: -28.11 (-30.30; -26.04), women, %: -0.28 (-0.47; -0.09)/mmol/mol: -0.28 (-0.47; -0.09)). INTERPRETATION Air pollution may be associated with higher HbA1c levels in newly diagnosed type 2 diabetes patients. Further studies are warranted to examine this association.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Air Pollution and Diabetes Risk: Assessing the Evidence to Date

Many studies have reported associations between ambient air pollution and cardiovascular disease, asthma, and cancer. Diabetes mellitus also is a risk factor for vascular and respiratory diseases, and development of these outcomes in people with diabetes may be exacerbated by exposure to air pollution. In this issue of EHP, a team of European scientists conducted a systematic review to evaluate...

متن کامل

Association between Ambient Air Pollution and Diabetes Mellitus in Europe and North America: Systematic Review and Meta-Analysis

BACKGROUND Air pollution is hypothesized to be a risk factor for diabetes. Epidemiological evidence is inconsistent and has not been systematically evaluated. OBJECTIVES We systematically reviewed epidemiological evidence on the association between air pollution and diabetes, and synthesized results of studies on type 2 diabetes mellitus (T2DM). METHODS We systematically searched electronic...

متن کامل

Exposure to indoor and outdoor air pollution among children under five years old in urban area

Indoor air pollution associated with cooking and heating biomass fuel burning is estimated to be responsible for 7 million deaths in 2016 and most of these deaths occur in low and middle income countries. In Côte d'Ivoire, 73% of the population is reported using biomass (charcoal or wood) for cooking. The active device 3M EVM-7 was used to measure PM2.5 daily average concentrations i...

متن کامل

Air Pollution and Type 2 Diabetes

According to the International Diabetes Federation in the year 2011, diabetes mellitus (DM) affects at least 366 million people worldwide, and that number is expected to reach 566 million by the year 2030. Over 99% of all diabetes cases represent type 2 DM with most of these projected to occur in lowto middle-income countries. Technology innovations, globalization with its free movement of food...

متن کامل

Ambient Air Pollution and Type 2 Diabetes: Do the Metabolic Effects of Air Pollution Start Early in Life?

The adverse health effects of ambient (outdoor) air pollution have been recognized since increased mortality due to smog was reported in London in 1952 (1). Suspended particles (particulate matters) from soot were associated with increased mortality and morbidity related to both respiratory and cardiovascular disorders (1). Since then, great efforts have been made to control ambient air polluti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2014